Prior to the Deadpool movie, barely anyone knew who Negasonic Teenage Warhead was. She made one appearance in Grant Morrison’s New X-Men run… and it was the issue in which she died! Joss Whedon briefly used Negasonic Teenage Warhead in Astonishing X-Men, but that was later revealed to be a ruse. She’s still dead, and the only reason she’s in Deadpool is because the producers liked her name. Brianna Hildebrand is portraying Negasonic Teenage Warhead, and her mutant powers include telepathy and precognition. She is also a student at Xavier’s School for Gifted Youngsters, which is run by Professor X and the X-Men.

Every hero needs a villain. And while Deadpool is more of an antihero, Ajax is his personal nemesis. Ed Skrein is portraying Ajax in the Deadpool movie, although he’ll be called by his real name, Francis. Within the comic book world, Ajax was a member of Weapon X who actually “killed” Deadpool by removing his heart. Deadpool’s heart grew back when his healing factor manifested itself, and he killed Ajax in revenge. Unfortunately for Deadpool, Ajax wasn’t as dead he thought he was. By the time that Ajax resurfaced in his life, he was stronger and smarter than Deadpool, with superspeed and an inability to feel pain. He’s still one of the most dangerous threats that Deadpool has ever faced.

Daniel Cudmore portrayed Colossus in three X-Men movies and barely got a chance to do anything with his character. Cudmore was offered the part in Deadpool, but he turned it down. Andre Tricoteux originally had the role of Colossus in Deadpool, and he performed most of the motion capture, before he was replaced by Stefan Kapičić late in the production. Colossus is one of the most prominent members of the second X-Men team that debuted in Giant-Sized X-Men #1 in 1975. His mutant power is that he can transform his body into organic steel. He doesn’t really have any connection to Deadpool, and his inclusion in this movie is kind of puzzling.

Blind Al is one of the more bizarre characters in Deadpool’s supporting cast, largely due to the nature of her relationship with Deadpool. She has alternately been Deadpool’s roommate, his maternal figure, his friend, and even his prisoner. Blind Al has also out-pranked Deadpool on numerous occasions, and it’s been hinted that she used to be an intelligence operative. Leslie Uggams will play Blind Al in the Deadpool movie, but it remains to be seen if the film will go as dark as the comic books did with Blind Al’s captivity at Deadpool’s hands.